Lateral augmentation of the mandible in minipigs with a synthetic nanostructured hydroxyapatite block
Identifieur interne : 004714 ( Main/Exploration ); précédent : 004713; suivant : 004715Lateral augmentation of the mandible in minipigs with a synthetic nanostructured hydroxyapatite block
Auteurs : Mark Kirchhoff [Allemagne] ; Solvig Lenz [Allemagne] ; Kai-Olaf Henkel [Allemagne] ; Bernhard Frerich [Allemagne] ; Gerd Holzhüter [Allemagne] ; Sven Radefeldt [Allemagne] ; Thomas Gerber [Allemagne]Source :
- Journal of Biomedical Materials Research Part B: Applied Biomaterials [ 1552-4973 ] ; 2011-02.
Descripteurs français
- Wicri :
- topic : Biomatériau.
English descriptors
- KwdEn :
- Alveolar ridge, Animal experiments, Appl biomater, Augmentation, Augmentation procedures, Autologous, Autologous bone grafts, Barrier membranes, Biomaterial, Biomaterial remnants, Biomaterial resorption, Biomaterials, Biomed mater, Biomedical materials research, Block graft, Block material, Bone formation, Bone repair, Bone tissue, Bony tissue, Calcium phosphate biomaterials, Cancellous bone, Carl zeiss, Central grindings, Clin, Compressive strength, Degradation, Dental implants, Different compositions, Distraction osteogenesis, Further development, Further resorption, Giant cells, Graft, Grafted area, Granule, Higher content, Higher rate, Human bone, Human jaws, Hydroxyapatite, Implant, Implantation, Intraoral approach, Lateral, Lateral aspect, Lateral augmentation, Lateral ridge augmentation, Macropores, Mandible, Matrix, Matrix change, Mechanical properties, Mercury method, Mercury porosimetry, Mineralized tissue, Minipigs, Nanometer range, Nanophase ceramics, Nanostructured, Online issue, Oral maxillofac implants, Oral pathol, Osteoblast, Osteoinduction, Outer layer, Pore, Pore diameter, Porosity, Research report table, Resorption, Screw head, Second peak, Short peptides, Silica, Silica matrix, Silica ratio, Sio2, Sio2 ratio, Soft tissue, Surface area, Surface areas, Titanium screws, Total porosity, Transmission electron, Vertical ridge augmentation, Wiley periodicals, Wound healing, Xenogenous block grafts.
- Teeft :
- Alveolar ridge, Animal experiments, Appl biomater, Augmentation, Augmentation procedures, Autologous, Autologous bone grafts, Barrier membranes, Biomaterial, Biomaterial remnants, Biomaterial resorption, Biomaterials, Biomed mater, Biomedical materials research, Block graft, Block material, Bone formation, Bone repair, Bone tissue, Bony tissue, Calcium phosphate biomaterials, Cancellous bone, Carl zeiss, Central grindings, Clin, Compressive strength, Degradation, Dental implants, Different compositions, Distraction osteogenesis, Further development, Further resorption, Giant cells, Graft, Grafted area, Granule, Higher content, Higher rate, Human bone, Human jaws, Hydroxyapatite, Implant, Implantation, Intraoral approach, Lateral, Lateral aspect, Lateral augmentation, Lateral ridge augmentation, Macropores, Mandible, Matrix, Matrix change, Mechanical properties, Mercury method, Mercury porosimetry, Mineralized tissue, Minipigs, Nanometer range, Nanophase ceramics, Nanostructured, Online issue, Oral maxillofac implants, Oral pathol, Osteoblast, Osteoinduction, Outer layer, Pore, Pore diameter, Porosity, Research report table, Resorption, Screw head, Second peak, Short peptides, Silica, Silica matrix, Silica ratio, Sio2, Sio2 ratio, Soft tissue, Surface area, Surface areas, Titanium screws, Total porosity, Transmission electron, Vertical ridge augmentation, Wiley periodicals, Wound healing, Xenogenous block grafts.
Abstract
The purpose of this study was to evaluate biomaterial degradation and new bone formation after implantation of a nanostructured hydroxyapatite (HA) grafting block. Furthermore, physical characteristics of the biomaterial were measured. The biomaterial consists of nanostructured HA embedded in a porous matrix of silica (SiO2) gel. The blocks with two different contents of silica (group A: 24 wt % and group B: 39 wt %) were fixed with titanium screws at the lateral aspect of the mandible of minipigs (n = 5). The specific surface areas of both blocks were measured using Brunauer–Emmett–Teller (BET) equation and mercury intrusion. In all animals, the wound healing was uneventful. After 5 weeks, the biomaterial percentage was 51.5% ± 12.1% for group A and 33.2% ± 5.9% for group B (p = 0.017). New bone formation accounted to 7.6% ± 6.0% for group A and 15.3% ± 8.3% for group B (p = 0.126) after 5 weeks. After 10 weeks, further resorption of the biomaterial led to percentages of 30.6% ± 10.0% for group A and 12.1% ± 6.7% for group B (p = 0.000). After 10 weeks, new bone formations were measured to be 34.1% ± 10.8% in group A and 39.9% ± 13.5% in group B (p = 0.383). The rate of degradation of the biomaterial is controlled by the composition of the material. A higher content of silica gel matrix leads to faster degradation of the biomaterial. The formation of new bone failed to show a significant difference between both groups. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.
Url:
DOI: 10.1002/jbm.b.31775
Affiliations:
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BIOMATERIALS</title><idno type="ISSN">1552-4973</idno><idno type="eISSN">1552-4981</idno><imprint><biblScope unit="vol">96B</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="342">342</biblScope><biblScope unit="page" to="350">350</biblScope><biblScope unit="page-count">9</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02">2011-02</date></imprint><idno type="ISSN">1552-4973</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1552-4973</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alveolar ridge</term><term>Animal experiments</term><term>Appl biomater</term><term>Augmentation</term><term>Augmentation procedures</term><term>Autologous</term><term>Autologous bone grafts</term><term>Barrier membranes</term><term>Biomaterial</term><term>Biomaterial remnants</term><term>Biomaterial resorption</term><term>Biomaterials</term><term>Biomed mater</term><term>Biomedical materials research</term><term>Block graft</term><term>Block material</term><term>Bone formation</term><term>Bone repair</term><term>Bone tissue</term><term>Bony tissue</term><term>Calcium phosphate biomaterials</term><term>Cancellous bone</term><term>Carl zeiss</term><term>Central grindings</term><term>Clin</term><term>Compressive strength</term><term>Degradation</term><term>Dental implants</term><term>Different compositions</term><term>Distraction osteogenesis</term><term>Further development</term><term>Further resorption</term><term>Giant cells</term><term>Graft</term><term>Grafted area</term><term>Granule</term><term>Higher content</term><term>Higher rate</term><term>Human bone</term><term>Human jaws</term><term>Hydroxyapatite</term><term>Implant</term><term>Implantation</term><term>Intraoral approach</term><term>Lateral</term><term>Lateral aspect</term><term>Lateral augmentation</term><term>Lateral ridge augmentation</term><term>Macropores</term><term>Mandible</term><term>Matrix</term><term>Matrix change</term><term>Mechanical properties</term><term>Mercury method</term><term>Mercury porosimetry</term><term>Mineralized tissue</term><term>Minipigs</term><term>Nanometer range</term><term>Nanophase ceramics</term><term>Nanostructured</term><term>Online issue</term><term>Oral maxillofac implants</term><term>Oral pathol</term><term>Osteoblast</term><term>Osteoinduction</term><term>Outer layer</term><term>Pore</term><term>Pore diameter</term><term>Porosity</term><term>Research report table</term><term>Resorption</term><term>Screw head</term><term>Second peak</term><term>Short peptides</term><term>Silica</term><term>Silica matrix</term><term>Silica ratio</term><term>Sio2</term><term>Sio2 ratio</term><term>Soft tissue</term><term>Surface area</term><term>Surface areas</term><term>Titanium screws</term><term>Total porosity</term><term>Transmission electron</term><term>Vertical ridge augmentation</term><term>Wiley periodicals</term><term>Wound healing</term><term>Xenogenous block grafts</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Alveolar ridge</term><term>Animal experiments</term><term>Appl biomater</term><term>Augmentation</term><term>Augmentation procedures</term><term>Autologous</term><term>Autologous bone grafts</term><term>Barrier membranes</term><term>Biomaterial</term><term>Biomaterial remnants</term><term>Biomaterial resorption</term><term>Biomaterials</term><term>Biomed mater</term><term>Biomedical materials research</term><term>Block graft</term><term>Block material</term><term>Bone formation</term><term>Bone repair</term><term>Bone tissue</term><term>Bony tissue</term><term>Calcium phosphate biomaterials</term><term>Cancellous bone</term><term>Carl zeiss</term><term>Central grindings</term><term>Clin</term><term>Compressive strength</term><term>Degradation</term><term>Dental implants</term><term>Different compositions</term><term>Distraction osteogenesis</term><term>Further development</term><term>Further resorption</term><term>Giant cells</term><term>Graft</term><term>Grafted area</term><term>Granule</term><term>Higher content</term><term>Higher rate</term><term>Human bone</term><term>Human jaws</term><term>Hydroxyapatite</term><term>Implant</term><term>Implantation</term><term>Intraoral approach</term><term>Lateral</term><term>Lateral aspect</term><term>Lateral augmentation</term><term>Lateral ridge augmentation</term><term>Macropores</term><term>Mandible</term><term>Matrix</term><term>Matrix change</term><term>Mechanical properties</term><term>Mercury method</term><term>Mercury porosimetry</term><term>Mineralized tissue</term><term>Minipigs</term><term>Nanometer range</term><term>Nanophase ceramics</term><term>Nanostructured</term><term>Online issue</term><term>Oral maxillofac implants</term><term>Oral pathol</term><term>Osteoblast</term><term>Osteoinduction</term><term>Outer layer</term><term>Pore</term><term>Pore diameter</term><term>Porosity</term><term>Research report table</term><term>Resorption</term><term>Screw head</term><term>Second peak</term><term>Short peptides</term><term>Silica</term><term>Silica matrix</term><term>Silica ratio</term><term>Sio2</term><term>Sio2 ratio</term><term>Soft tissue</term><term>Surface area</term><term>Surface areas</term><term>Titanium screws</term><term>Total porosity</term><term>Transmission electron</term><term>Vertical ridge augmentation</term><term>Wiley periodicals</term><term>Wound healing</term><term>Xenogenous block grafts</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Biomatériau</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of this study was to evaluate biomaterial degradation and new bone formation after implantation of a nanostructured hydroxyapatite (HA) grafting block. Furthermore, physical characteristics of the biomaterial were measured. The biomaterial consists of nanostructured HA embedded in a porous matrix of silica (SiO2) gel. The blocks with two different contents of silica (group A: 24 wt % and group B: 39 wt %) were fixed with titanium screws at the lateral aspect of the mandible of minipigs (n = 5). The specific surface areas of both blocks were measured using Brunauer–Emmett–Teller (BET) equation and mercury intrusion. In all animals, the wound healing was uneventful. After 5 weeks, the biomaterial percentage was 51.5% ± 12.1% for group A and 33.2% ± 5.9% for group B (p = 0.017). New bone formation accounted to 7.6% ± 6.0% for group A and 15.3% ± 8.3% for group B (p = 0.126) after 5 weeks. After 10 weeks, further resorption of the biomaterial led to percentages of 30.6% ± 10.0% for group A and 12.1% ± 6.7% for group B (p = 0.000). After 10 weeks, new bone formations were measured to be 34.1% ± 10.8% in group A and 39.9% ± 13.5% in group B (p = 0.383). The rate of degradation of the biomaterial is controlled by the composition of the material. A higher content of silica gel matrix leads to faster degradation of the biomaterial. The formation of new bone failed to show a significant difference between both groups. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Hambourg</li></region><settlement><li>Hambourg</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Kirchhoff, Mark" sort="Kirchhoff, Mark" uniqKey="Kirchhoff M" first="Mark" last="Kirchhoff">Mark Kirchhoff</name></noRegion><name sortKey="Frerich, Bernhard" sort="Frerich, Bernhard" uniqKey="Frerich B" first="Bernhard" last="Frerich">Bernhard Frerich</name><name sortKey="Gerber, Thomas" sort="Gerber, Thomas" uniqKey="Gerber T" first="Thomas" last="Gerber">Thomas Gerber</name><name sortKey="Henkel, Kai Laf" sort="Henkel, Kai Laf" uniqKey="Henkel K" first="Kai-Olaf" last="Henkel">Kai-Olaf Henkel</name><name sortKey="Holzhuter, Gerd" sort="Holzhuter, Gerd" uniqKey="Holzhuter G" first="Gerd" last="Holzhüter">Gerd Holzhüter</name><name sortKey="Kirchhoff, Mark" sort="Kirchhoff, Mark" uniqKey="Kirchhoff M" first="Mark" last="Kirchhoff">Mark Kirchhoff</name><name sortKey="Lenz, Solvig" sort="Lenz, Solvig" uniqKey="Lenz S" first="Solvig" last="Lenz">Solvig Lenz</name><name sortKey="Radefeldt, Sven" sort="Radefeldt, Sven" uniqKey="Radefeldt S" first="Sven" last="Radefeldt">Sven Radefeldt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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